p73: a Positive or Negative Regulator of Angiogenesis, or Both?

p73: a Positive or Negative Regulator of Angiogenesis, or Both?

The role of p73, the homologue of the tumor suppressor p53, in regulating angiogenesis has recently been extensively investigated, resulting in the publication of five articles. Of these, two studies suggested a suppressive role, while the others implied a stimulatory role for the p73 isoforms in regulating angiogenesis. A negative role for TAp73, the full-length form that is often associated w...

Positive Woman or Negative Man?

a-Synuclein – Regulator of Exocytosis, Endocytosis, or Both?

a-Synuclein is known as a presynaptic protein that binds to small synaptic vesicles. Recent studies suggest that a-synuclein is not only attracted to these tiny and therewith highly curved membranes, but that in fact the sensing and regulation of membrane curvature is part of its physiological function. Moreover, recent studies have suggested that a-synuclein plays a role in the endocytosis of ...

Fasting and Experimental Animals, Detrimental or Positive?

While fasting has been practiced for centuries, its beneficial effects was unknown until recently. This review tries to analyze the current literature of how fasting and intermittent fasting (IF) could affect clinical pathological parameters, learning, mood and brain plasticity. The effects of different ways of fasting on metabolism and stress were also explored. Animal experiments have elucida...

Browser-Based Applications: Positive or Negative Transference?

Applications that run on top of web browsers dominate the Internet today. Given the many similarities among these applications’ features, positive transference from one to another is often seen as an important source of ease-of-use for such applications. This paper examines the many differences in the way similar features are implemented in different browserbased applications, analyzing the way...